Evaluation of 14-3-3σ as a Prognostic Marker in Canine Mammary Tumors
DOI:
https://doi.org/10.52331/v30i20s71Keywords:
14-3-3 σ, immunohistochemistry, canine mammary gland tumor.Abstract
14-3-3σ is a regulatory protein involved in cell cycle control and has been implicated in both tumor-suppressive and tumor-promoting roles, depending on the biological context. While extensively studied in human cancers, limited information is available regarding its expression in canine mammary gland tumors. This study aimed to assess the immunohistochemical expression of 14-3-3σ in canine mammary tumors and evaluate its potential association with malignancy indicators such as histological grade and mitotic index. A total of 62 tumor samples were analyzed using immunohistochemistry, and the area of 14-3-3σ expression was digitally quantified. Statistical comparisons were performed using non-parametric tests. An inverse trend was observed between 14-3-3σ expression and both tumor grade (p = 0.051) and mitotic (p = 0.0090) activity. These findings suggest a potential link between decreased 14-3-3σ expression and increased malignancy, supporting its relevance as a candidate prognostic marker in canine mammary tumors. Further studies with larger cohorts are needed to validate these observations.
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Copyright (c) 2025 Ana Hiruta, Andrada Negoescu, Zoltán-Miklós GÁL , Alexandru Raul Pop, Cornel Cătoi
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