Doxazosin Effect on Neurogenic Bladder with Urine Retention in Female Dogs
Keywords:α1-adrenergic blocking agent, α adrenoreceptor, neurogenic bladder
Abstract: This short communication describes the effect of Doxazosin in case of urinary retention in female dogs due to motor neuron lesions produced by spinal trauma or spinal compression consecutively to intervertebral disk degeneration and extrusion. The study aims to determine whether the treatment of urinary retention in case of neurogenic bladder in female dogs, using 1 adrenergic blocker is effective in spontaneous recovery of the examined patients. Ten female dogs presenting with urinary retention were examined in the laboratory of Radiology, Faculty of Veterinary Medicine Cluj Napoca. The patients were examined using CT, radiography and ultrasonography in order to identify the spinal cord injury that is responsible for neurogenic bladder. The dose of Doxazosin used in treatment of voiding problem in neurogenic bladder was 1mg/kg, single dose per day. Depending on the spinal cord compression cause, the urine retention symptom was resolved.
Bali, M.S.; Lang, J.; Jaggy, A.; Spreng, D.; Doherr, M.G.; Forterre, F. Comparative Study of Vertebral Fractures and Luxations in Dogs and Cats. Vet Comp Orthop Traumatol 2009, 1, 47–53, doi:10.3415/VCOT-08.
Bagley, R. Spinal Fracture or Luxation. Veterinary Clinics of North America: Small Animal Practice 2000, 30, 133–153.
Forterre, F.; Gorgas, D.; M, D.; Jaggy, A.; Lang, J.; Spreng, D. Incidence of Spinal Compressive Lesions in Chondrodystrophic Dogs with Abnormal Recovery after Hemilaminectomy for Treatment of Thoracolumbar Disc Disease: A Prospective Magnetic Resonance Imaging Study. Veterinary Surgery 2010, 39, 165–172, doi:10.1111/j.1532-950X.2009.00633.x.
Nishizawa, O.; Sugaya, K. Cat and Dog: Higher Center of Micturition. Neurourol Urodyn 1994, 13, 169–79.
Yoshimura, N. Bladder Afferent Pathway and Spinal Cord Injury : Possible Mechanisms Inducing Hyperreflexia of the Urinary Bladder. Progress in Neurobiology 1999, 57, 583–606.
Bennett, B.C.; Roppolo, J.R.; Kruse, M.N.; de Groat, W.C. Neural Control of Urethral Smooth and Striated Muscle Activity in Vivo: Role of Nitric Oxide. J. Urol. 1995, 153, 2004–2009.
Black, J.A.; Langworthy, K.; Hinson, A.W.; Dib-Haji, S.D.; Waxman, S.G. NGF Has Opposing Effects on Na+ Channel III and SNS Gene Expression in Spinal Sensory Neurons. NeuroReport 1997, 8, 2331–2335.
Ramage, A.G.; Wyllie, M.G. A Comparison of the Effects of Doxazosin and Terazosin on the Spontaneous Sympathetic Drive to the Bladder and Related Organs in Anaesthetized Cats. Eur.J. Pharmacol. 1995, 294, 645–650.
Sugaya, K.; Nishijima, S.; Miyazato, M.; Ashitomi, K.; Hatano, T.; Ogawa, Y. Effects of Intrathecal Injection of Tamsulosin and Naftopidil, Alpha-1A and -1D Adrenergic Receptor Antagonists, on Bladder Activity in Rats. Neurosci.Lett. 2002, 328, 74–76.
Michel, M.C.; Vrydag, W. Α 1-, Α 2- and Β-Adrenoceptors in the Urinary Bladder, Urethra and Prostate. British Journal of Pharmacology 2006, 147, 88–119, doi:10.1038/sj.bjp.0706619.
Andersson, K.; Lepor, H.; Wyllie, M. Prostatic Α1-Adenoreceptors and Uroselectivity. Prostate. 1997, 30, 205–215.
Nitti, V.W. Is There a Role for Alpha-Blockers for the Treatment of Voiding Dysfunction Unrelated to Benign Prostatic Hyperplasia? Reviews in urology 2005, 7 Suppl 4, S49-55.
Restorick, J.; Mundy, A. The Density of Cholinergic and Alpha and Beta Adrenergic Receptors in the Normal and Hyper-Reflexic Human Detrusor. Br J Urol. 1989, 63, 32–5.
Jeong, M.S.; Lee, J.G. The Role of Spinal and Peripheral A1- and A2-Adrenoceptors on Bladder Activity Induced by Bladder Distension and Anaesthetized Rat. BJU Int. 2000, 85, 925–931.
Fischer, J.R.; Cribb, A.E. Urethral Pressure Profile and Hemodynamic Effects of Phenoxybenzamine and Prazosin in Non-Sedated Male Beagle Dogs Résumé. 1. Fischer JR, Cribb AE. Urethral pressure profile and hemodynamic effects of phenoxybenzamine and prazosin in non-sedated male beagle dogs Résumé. 2003;(858):30–8. 2003, 67, 30–38.
Karadenİz, A.; Pİşkİn, İ.; Eşsİz, D.; Altintaş, L. Relaxation Responses of Trigonal Smooth Muscle from Rabbit by Alpha 1 - Adrenoceptor Antagonists Alfuzosin , Doxazosin and Tamsulosin Urinary Bladder Dysfunction Secondary to Benign Prostate Hyperplasia ( BPH ) in Humans and Animals Is a Major Health Prob. Acta Veterinaria Brno 2008, 77, 81–88, doi:10.2754/avb200877010081.
Bubenik, L.J.; Hosgood, G.L.; Waldron, D.R.; Snow, L.A. Frequency of Urinary Tract Infection in Catheterized Dogs and Comparison of Bacterial Culture and Susceptibility Testing Results for Catheterized and Noncatheterized Dogs with Urinary Tract Infections. Journal of the American Veterinary Medical Association 2007, 231, 893–899, doi:10.2460/javma.231.6.893.
Olby, N.J.; Mackillop, E.; Moore, S.; Mun, K.R.; Grafinger, M.; Osborne, J.A.; Vaden, S.L. Prevalence of U Rinary Tract I Nfection in Dogs a Fter Surgery f or Thoracol Umbar I Ntervertebral Di Sc Extrusi On. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2010, 1106–1111.
Hu, H.Z.; Granger, N.; Jeffery, N.D. Pathophysiology, Clinical Importance, and Management of Neurogenic Lower Urinary Tract Dysfunction Caused by Suprasacral Spinal Cord Injury. Journal of Veterinary Internal Medicine 2016, 30, 1575–1588, doi:10.1111/jvim.14557.
Young, R.; Brogden, R. Doxazosin: A Review of Its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy in Mild or Moderate Hypertension. Drugs. 1988, 35, 525–41.
Khoury, A.; Kaplan, N. α-Blocker Therapy of Hypertension. JAMA. 1991, 266, 394–8.
Yuan, J.; Liu, Y.; Yang, Z.; Qin, X.; Yang, K.; Mao, C. The Efficacy and Safety of Alpha-1 Blockers for Benign Prostatic Hyperplasia: An Overview of 15 Systematic Reviews. Current Medical Research and Opinion 2013, 29, 279–87.
Calin, A.M.; Grigore, A.C.; Voicu, D.C.; Schaas, M.C. Toxic-Septic Abortion and Its Severe Complications, Frequently Lethal. Revista de Chimie 2016, 67, 2618–2622.
Uemura, EE. Chapter 22. Autonomic nervous system. In Fundamentals of Canine Neuroanatomy and Neurophysiology; Wiley-Blackwell, 2015; pp. 383–410.
Samson, M.; Reddy, VK. Localization of the Sacral Parasym- Pathetic Nucleus in the Dog. Am J Vet Res 1982, 43, 1833–1836.
Smith, P.M.; Jeffery, N.D. Spinal Shock-Comparative Aspects and Clinical Relevance. Journal of Veterinary Internal Medicine 2005, 19, 788–793, doi:10.1111/j.1939-1676.2005.tb02766.x.
Taweel, W. Al; Seyam, R. Neurogenic Bladder in Spinal Cord Injury Patients. Research and Reports in Urology 2015, 7, 85–99, doi:10.2147/RRU.S29644.
Kaye, B.; Cussans, N.J.; Stopher, D.A.; Hospital, S.G. The Metabolism and Kinetics of Doxazosin in Man, Mouse, Rat and Dog. Br. J. clin. Pharmac. 1986, 21.
Haagsman, A.N.; Kummeling, A.; Moes, M.E.; Mesu, S.J.; Kirpensteijn, J. Comparison of Terazosin and Prazosin for Treatment of Vesico-Urethral Reflex Dyssynergia in Dogs. Veterinary Record 2013, 173, 41–41, doi:10.1136/vr.101326.
Serels, S.; Stein, M. Prospective Study Comparing Hyoscyamine, Doxazosin, and Combination Therapy for the Treatment of Urgency and Frequency in Women. Neurourol Urodyn 1998, 17, 31–6.
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